|
KMID : 0356620150300020221
|
|
Journal of Korean Society of Endocrinology
2015 Volume.30 No. 2 p.221 ~ p.225
|
|
|
A Calcitonin-Negative Neuroendocrine Tumor Derived from Follicular Lesions of the Thyroid
|
|
:Kim Ga-Young
:Park Chul-Yun/:Cho Chang-Ho/:Park June-Sik/:Jung Eui-Dal/:Jeon Eon-Ju
|
|
|
Abstract
|
|
|
|
Neuroendocrine lesions of the thyroid are rare. The most common types are medullary thyroid carcinomas (MTCs) and C-cell hyperplasia. MTCs originate from thyroid parafollicular cells that secrete calcitonin which serves as a serum marker of MTCs. Here, the rare case of a calcitonin-negative neuroendocrine tumor (NET) derived from follicular lesions of the thyroid is described. A 34-year-old man presented at our hospital for the surgical management of an incidental thyroid nodule that was observed on an ultrasound sonography (USG) of the neck. Initially, USG-guided aspiration cytology was performed, and a MTC was suspected. The expressions of thyroglobulin and thyroid transcription factor-1, which are thyroid follicular cell markers, and synaptophysin and chromogranin A, which are neuroendocrine markers, was confirmed following surgical pathology. However, the staining of calcitonin, a marker of MTCs, was not observed. A nonmedullary NET of the thyroid is uncommon, and the distinction between calcitonin-negative NETs and MTCs of the thyroid may be important due to differences in their clinical courses and management.
|
|
|
KEYWORD
|
|
|
Calcitonin, Carcinoma, medullary, Neuroendocrine tumors
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|
|